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Description
GLP-1RAs improve insulin sensitivity, reduce hepatic steatosis, and attenuate systemic inflammatory mediators, thereby targeting upstream drivers of autoimmunity [54,55]

Why havent GLP-1 agonists been approved for NASH

Factors such as diet, physical activity, sleep quality, underlying medical conditions, other medications, and individual metabolism can all influence both side effects and overall results

Patients with high baseline triglycerides ( 150 mg/dL) levels showed a relatively greater reduction in apoC-III compared with those presenting normal levels
We modeled an optimistic scenario using the best possible weight loss outcomes and long-term risk reductions, said first author Jennifer Hwang, DO, a primary care physician at UChicago Medicine
