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Description
2020;22(Suppl 1):314
The oral semaglutide offered through MadeMed is a compounded sublingual formulation - it is not the same product, does not use the same proprietary absorption technology, and has not been independently evaluated by the FDA for bioavailability, dosing equivalence, or absorption characteristics relative to the FDA-approved version
This may have resulted from the timing of the study relative to the COVID-19 pandemic (SURMOUNT-1 and STEP during, ONeil and SCALE Obesity and Prediabetes prior), which may have impacted the reporting of safety events
Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial
Alcohol is a natural diuretic that increases urination and fluid loss
