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Pivotal studies, such as the STEP-HFpEF and SELECT trials, have now expanded their indication to heart failure with preserved ejection fraction (HFpEF) and to non-diabetic populations with obesity and CVD, respectively [11,12]

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[14] This occurs because they increase urinary glucose excretion, creating a favourable environment for bacterial and fungal growth

The current study presents compelling preclinical and clinical evidence that SANA is a potent drug for the treatment of DIO, with a primary mechanism of action being the activation of creatine-dependent energy expenditure and thermogenesis in adipose tissue

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