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Safety concerns were also raised in a phase 1 trial investigating the GLP-1R/GCGR agonist NNC9204-117, where a dose-dependent increase in heart rate was observed, in addition to increased markers of inflammation, hepatic disturbances, impaired glucose tolerance, and reduced blood levels of some amino acids despite clinically relevant weight loss (Friedrichsen et al

GLP-1 RAs, such as exenatide and lixisenatide, have shown benefits in addressing the pathology of PD in animal studies and phase II clinical trials, halting progression and delaying worsening of symptoms

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[3] [4] While human evidence for direct dopamine modulation is more limited, the clinical effect translates into patients reporting that food seems less appealing, cravings diminish, and the mental space occupied by food-related thoughts decreases substantially

doi: 10.2337/diab.41.9.1042 38 DucaLMMaahsDMSchauerIEBergmanBCNadeauKJBjornstadPet al