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In humans, higher body weight and waist circumference are associated with impaired satiation, indicated by more calories consumed before terminating a meal (43)

Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau

Clinical trials, like SURMOUNT-1, have indicated promising results in weight reduction, underscoring Zepbounds effectiveness

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Many people using GLP-1 drugs for weight loss notice the so-called Ozempic face, a hollowed or sunken appearance, especially around the cheeks and jawline