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Symptoms of OSA may include snoring, low sleep quality with frequent arousal, daytime sleepiness, mouth dryness on awakening and headaches

Study 5 enrolled 234 patients who were unable or unwilling to use Positive Airway Pressure (PAP) therapy and Study 6 enrolled 235 patients who were on PAP therapy

Many people achieve satisfactory results at 10mg or 12.5mg, and the clinical trials showed meaningful weight loss at every dose level above 5mg

Gadde KM, Martin CK, Berthoud H-R, Heymsfield SB

The most common side effects are gastrointestinal, including: Nausea Diarrhea Vomiting Constipation These are dose-dependent and usually mild to moderate
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