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GLP-1/GLP-1R functions in different knee joint tissues OA is a whole-joint degenerative disease, and pathological changes seen in OA include degradation of cartilage, synovial inflammation and thickening of subchondral bone with osteophyte formation, associated with symptoms such as pain and stiffness

[2] Wilding, J

These divergent effects appear to be modulated by multiple factors, including treatment duration, drug concentration, cancer type, and patient-specific parameters such as genetic background and comorbidities [9, 19]
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An unexpected benefit of taking a GLP-1