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Description
In islet alpha cells, GLP-1(936) led to inhibition of Ca2+ entry via voltage-gated Ca2+ channels sensitive to -agatoxin, with consequential pertussis-toxin-sensitive depletion of the docked pool of secretory granules, effects that were prevented by the glucagon receptor antagonists REMD2.59 and L-168049

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Secondary outcomes included all-cause mortality, cardiovascular mortality, hospitalisation for heart failure, a kidney composite endpoint and serious adverse events

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Originally designed to manage type 2 diabetes (T2D), these drugs have rapidly expanded their therapeutic reach, offering significant benefits for ob
