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Bariatric surgery may improve body weight, glucose metabolism, and inflammation by the gut microbiota-secondary BA-GLP-1 mechanism (11)

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All these trials were designed to evaluate the primary outcome of 3-MACE defined as cardiovascular death, nonfatal myocardial infarct, and nonfatal stroke, except for the ELIXA trial of exenatide ER, which included hospitalization for unstable angina as an additional component of the 4-MACE composite outcomes