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B6 mice fed with a normal fat diet (Normal Diet) or HFD (DIO) received the following treatment regimens: saline (Saline), scExe4 donor DNA-loaded LNP (Donor), or scExe4 donor DNA plus Cas9-coding DNA-loaded LNP (Donor+Cas9)

Highlights: Nearly 40% of patients stopped GLP-1 therapy within the first year More than half of those who stopped later restarted treatment Side effects, cost, and access barriers were common reasons for treatment interruptions Reduce appetite Improve blood sugar control Promote weight loss Lower the risk of certain cardiovascular complications Trusted Source Discontinuation and Reinitiation of Dual-Labeled GLP-1 Receptor Agonists Among US Adults With Overweight or Obesity Go to source)

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Start with 3 grams daily for the first week, then increase to 5 grams if no issues arise

These issues can include blurred vision, worsening diabetic retinopathy, and problems related to the optic nerve