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N Engl J Med 373(23):22472257 Rahmoune H, Thompson PW, Ward JM, Smith CD, Hong G, Brown J (2005) Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with noninsulin- dependent diabetes

The clinical model reflects that distinction
Tirzepatide (Mounjaro, Zepbound) often costs about $1,050 to $1,350 per month
Even mild dehydration reduces metabolic efficiency
But biological plausibility is not the same as clinical proof
