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Social media as pharmacovigilance: the potential for patient reports to inform clinical research on glucagon-like peptide 1 (GLP-1) receptor agonists for substance use disorders

Vos T, Lim SS, Abbafati C et al

The proportional hazards assumptions were tested using the generalized Schoenfeld approach [47]

This is due to underreporting of overweight and obesity diagnoses in the Danish registries, and the fact that GLP-1 receptor agonists were not approved for the treatment of obesity until December 2022

As such, discontinuing therapy solely based on normalized HbA1c may deprive patients, especially those with underlying cardiovascular or renal risk, of organ-protective effects that are both substantial and sustained