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The efficacy, safety, and potential of oral glucagon-like peptide-1 (GLP-1) 2025, orforglipron, in oral obesity treatment were demonstrated because, in the ATTAIN-1 Phase 3 study, in 72 weeks, the average weight loss was 12.4 percent and cardiometabolic risk factors were improved (Eli Lilly, 2018)

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Nature Reviews Gastroenterology & Hepatology , 16(1), 3556

Nathanson D, Ullman B, Lfstrm U, Hedman A, Frick M, Sjholm A, Nystrm T: Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety