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In addition, PVH GLP-1R knockout in juvenile mice led to increased adult body weight and food intake with no changes in energy expenditure, suggesting potential compensatory adaptation during development [94]

doi: 10.1186/s40478-021-01180-z [DOI] [PMC free article] [PubMed] [Google Scholar] 229

Moreover, the results of cardiovascular outcome trials in persons with T2D given GLP-1RA demonstrating reduced stroke, myocardial infarction, and cardiovascular death 35 along with the emerging evidence demonstrating positive effects of GLP-1RAs 36,37 on kidney outcomes adds further impetus that these drugs have pleiotropic benefits

These molecules, which have made waves in the treatment of obesity and Type 2 diabetes through medications such as Ozempic, Wegovy and Zepbound, are more stable than their natural counterparts, thus increasing their therapeutic potential

Avoid anything with added sugars or refined carbohydrates, as these can undermine your progress and leave you feeling worse, not better