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doi: 10.1517/17425255.2014.907274

Journal reference: Petersen, J., Ludwig, M.Q., Juozaityte, V., et al

1 , 2 We present a case of a 62-year-old woman with clinicopathologic features consistent with FDE secondary to injections of semaglutide (Ozempic, Novo Nordisk, Bagsvrd, Denmark), a glucagon-like peptide 1 (GLP-1) receptor agonist used as an adjunct to diet and exercise to improve glycemic control and to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus (DM)
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Studies in rodents have demonstrated that SGLT2i treatment increases the synthesis of the ketone 3-hydroxybutyrate, which modifies histone H3K9 expression in adipocytes, consequently upregulating adiponectin synthesis in adipocytes [76]
