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Always work with your healthcare provider when adjusting doses

Importantly, the European Medicines Agency's Pharmacovigilance Risk Assessment Committee (PRAC) concluded in 2024 that current evidence does not support a causal link between GLP-1 receptor agonists, including semaglutide, and suicidal thoughts or self-injurious behaviour

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It was used in a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, and the general safety and tolerability of MEDI0382 were established, as was its placebo-corrected efficacy in reducing fasting blood glucose (1.7 mmol/L), postprandial glucose excursions following a mixed meal test (22.6% area under the curve 04 hours), body weight (2.1 kg), and liver fat (19.6%)

After reviewing new data, she began tirzepatide, achieved 22 pounds of weight loss, and has remained pancreatitis-free for over a year