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The reckoning for investors arrived on August 5, 2025, when a dramatic lowering of the full-year guidance triggered a massive sell-off

conducted a retrospective cohort study and found that there was a significantly lower risk of HHF in patients with T2DM, overweight/obesity, and HFpEF receiving GLP-1 RA plus SGLT2i therapy compared with the SGLT2i-only therapy, suggesting a potential incremental benefit of GLP-1 RA [81]

These oral non-peptides could dramatically simplify treatment by avoiding the strict empty-stomach dosing requirements of peptide-based oral semaglutide

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The Cochrane Collaboration