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Identifying Your Risk: Genetic Factors and Personalized Assessment Not everyone who takes semaglutide experiences OCD symptoms, which suggests that individual genetic and neurobiological factors play a critical role

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Coupled with cost-effectiveness concerns, the BCBSA data suggesting that many patients dont stay on their obesity medications long enough to experience clinically meaningful benefit present challenges for insurers making payment decisions regarding GLP-1s for weight loss.

Notably, previous analyses of the SURPASS trials suggest that tirzepatide-induced sustained and significant weight loss is independent of GI AEs [44], similar to findings with once-weekly semaglutide 2.4 mg [45]