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The Dysesthesia Safety Signal The most-discussed Phase 3 finding has been dysesthesia abnormal skin sensations including tingling, burning, or pricking reported at 20.9% incidence at the 12 mg dose versus 0.7% on placebo in TRIUMPH-4

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Overall results support Chen et al.s observation that 1.25 g sorbitol can impact Class III drug absorption

Adding to the discussion, a 2025 study from the University of Michigan, presented at the Endocrine Societys annual meeting, found that obese mice treated with tirzepatide lost about 20% of their body weight and developed significantly smaller breast tumors than control mice

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