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GLP-1 as a Longevity / Systems Platform EVIDENCE TIER, MULTI-OMIC ASSOCIATION + EDITORIAL POSITION In April 2026, Cell Metabolism published a multi-omic analysis of GLP-1 receptor agonist effects across organ systems that, in the careful language scientists use when they suspect they are looking at something larger than the immediate hypothesis, characterized the changes as body-wide and consistent with broad anti-aging signatures. The methodology is worth pausing on

The intervention involved a once-daily administration of oral semaglutide at dose of 14 mg, while the comparators consisted of once-weekly injectable semaglutide at 1.0 mg, once-weekly dulaglutide at 1.5 mg, once-daily liraglutide at 1.8 mg, twice-daily exenatide at 10 ug, and once-daily lixisenatide at 20 ug (Supplementary Table S2)

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What if I want to try a GLP-1 for a condition other than weight loss or diabetes

A population-based analysis of distinguishers of bipolar disorder from major depressive disorder