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What matters most is consistency over time

Spot reduction is not realistic

General guidance suggests approximately 1.21.6 grams of protein per kilogram of ideal body weight daily, distributed across meals, though this should be personalised with advice from a registered dietitian, particularly for those with kidney disease

By addressing these long-standing eating behaviors and their consequent biological sequelae, a sustainable healthy lifestyle foundation can be better established

Currently, many clinical practice guidelines, including the consensus guideline of the American Diabetes Association and the European Association for the Study of Diabetes, recommend glucagon-like peptide-1 receptor agonist (GLP-1RA) as the first-line injectable agent ahead of basal insulin for most patients with T2DM ( So far, two different products containing fixed-ratio combinations (FRCs) of basal insulin and GLP-1RA were approved by the US Food and Drug Administration and European Medicines Agency: IGlarLixi, which is a combo of insulin glargine and lixisenatide, and IDegLira, which is a combo of insulin degludec and liraglutide ( Based on these backgrounds, this study aimed to evaluate the overall effect of adding basal insulin on persisting GLP-1RA treatment