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Description
The gradual dose titration schedule recommended in the prescribing information is specifically designed to minimize these gastrointestinal effects
These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88
doi: 10.1210/jcem-37-5-826 [DOI] [PubMed] [Google Scholar] 12
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