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Fetissov et al., 2002

[DOI] [PMC free article] [PubMed] [Google Scholar] [40].Kyriakidou A, Kyriazou AV, Koufakis T, et al

These non-oral options bypass the absorption issue entirely because they do not depend on gastrointestinal uptake

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Evidence comes from large-scale studies such as the SCALE and LEAD trials for liraglutide, the STEP 18 program for semaglutide, the SURMOUNT 14 trials for tirzepatide, AWARD-11 for dulaglutide, and DURATION-1 for exenatide (Table 3)
