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No, patients should continue prescribed arthritis medications and maintain comprehensive joint care as directed by their healthcare providers

There is evidence showing that GLP-1RAs can reduce the expression of cell apoptotic markers Bcl-2-associated x (Bax) and caspase-3 while upregulating Bcl-2 [99, 100], as well as protecting against lipotoxic stress via phosphoinositide 3-kinase (PI3K)/Akt/forkhead box proteins O1 (FoxO1) pathway [101]

If youve read my series on GIP, you may guess what this means for patient outcomes

Those who recevied the placebo (no active drug) on average experienced 14% weight regain whilst those who continued on Tirzepatide had a further average weight loss of 5.5%

however, not all of that weight loss comes from fat