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A 2022 systematic review found mixed outcomes: some gastroparesis patients tolerated low-dose GLP-1 therapy without symptom exacerbation, while others experienced significant worsening

Chronic weight management in people with obesity or overweight Tirzepatide and semaglutide are also used to help with long-term weight management in people who are overweight or obese (BMI 30 or higher)

You cannot prevent the metabolic changes that cause cold sensitivity, but you can manage the discomfort through layering, staying hydrated, eating adequate protein, and maintaining physical activity to preserve muscle heat production

Obesity is a chronic relapsing disease in the same way