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This article provides a summary of the weight reduction effectiveness, glycemic control, and safety of semaglutide (up to a 2.4-mg dose) and tirzepatide (up to a 15-mg dose), with a focus on the Semaglutide Treatment Effect in People with Obesity (STEP) 2, SURPASS-1, and SURPASS-2 trials, which involved patients with type 2 diabetes mellitus

Phase 2 clinical trials published in 2023 reported mean resting heart rate increases of approximately 5 to 7 beats per minute at higher doses (8 mg and 12 mg weekly)

combining these with semaglutide amplifies constipation risk

Always verify with your provider before starting treatment to understand your insurance coverage

Increase gradually to avoid gas and bloating, which are already common during semaglutide dose escalation