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PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use

In addition to that, tirzepatide influences the expression of microtubule-associated protein 2 (MAP2), growth-associated protein 43 (GAP43), and ATP/GTP binding protein-like 4 (AGBL4), which are involved in neuronal differentiation and synaptic plasticity

That growth has already been enjoyed by shareholders of the companies dominating that space, including Novo Nordisk NYSE: NVO, maker of Ozempic and Wegovy, and Eli Lilly NYSE: LLY, maker of Zepound and Mounjaro

2019;316(2):C13553

Yes, and this is where things get interesting