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Myth #12: Everyone Who Loses Weight Ends Up Worse Than Before The Claim: People lose weight then regain it all plus extra, ending up heavier and more metabolically damaged than when they started (Reddit r/antidiet post) The Reality: Weight cycling is concerning, but medication-assisted weight loss followed by maintenance (either through continued medication or lifestyle) doesnt lead to worse outcomes than never losing weight

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For most, the bigger narrative is how these shifts echo throughout the body

Cell Metab 9(3):252264 Bindesbll C, Fan Q, Nrgaard RC, MacPherson L, Ruan H-B, Wu J et al (2015) Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity

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