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Onset of Appetite Suppression The time it takes for tirzepatide to suppress appetite varies among individuals: Within Hours: Some individuals may experience appetite suppression within hours (some individuals on Reddit report 12 24 hours with 2.5mg) due to heightened sensitivity to incretin hormones or variations in central nervous system receptors

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GIP activity in the central nervous system may have additional metabolic advantages by lowering energy expenditure in addition to enhancing lipid management in the periphery, particularly when paired with GLP-1 [6]