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A phase 1b/2a trial of the weekly subcutaneous administration was conducted to assess safety, tolerability, pharmacokinetics and dose-related effects on body weight (83)

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In the Vehicle and Baseline control conditions, when the more palatable food was available in S2, the animals reduced their consumption in S1 anticipating the more valued meal, so that the consumption decrement in S1 matched the excess amount eaten in S2 we referred to this phenomenon as the palatability-driven negative anticipatory effect [34]

Liver-targeting medications (such as resmetirom, fibroblast growth factor 21 analogs and lanifibranor), aiming at liver inflammation and collagen deposition, are expected to become crucial in individuals with more advanced liver disease [138]

The shift toward personalized care enabled by this report is echoed by Dr