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These immune-mediated events were compounded by intolerable gastrointestinal side effects, including nausea in 59% and vomiting in 37% of participants, along with reports of acute pancreatitis, culminating in a dropout rate of 2634% in Phase 3 trials [65]

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Some temporary weight fluctuation (1-3 pounds) is normal during the transition period as your body adjusts to the new medication

Impact on body weight: GLP-1 receptor activation tends to promote weight loss, while GIP receptor activation may promote weight gain through its effects on fat storage
