glp-1 negative effects GI Adverse of Glucagon-Like Peptide-1 Receptor Agonists GLP-1R Agonists for Weight Loss

GLP-1 RA glucagon-like peptide 1 receptor agonists, CI confidence interval, MACE major adverse cardiovascular event, MI myocardial infarction, SBP systolic blood pressure in mmHg, HR hazard ratio, RR relative risk, HF heart failure, LVEF left-ventricular ejection fraction a Primary or secondary outcome of interest as reported by the study Statistically significant confidence interval Major Adverse Cardiac Events Among Patients with T2DM Strong evidence supports using GLP-1 RAs to reduce MACE among patients with T2DM and established CVD

He holds a PhD in materials chemistry from Uppsala University

In the heart and vasculature, reduced inflammation and improved endothelial energetics translate into fewer heart attacks and strokes

doi: 10.1126/science.aah4967 [DOI] [PMC free article] [PubMed] [Google Scholar] 119

We focused on AEs with severe outcomes, while also analyzing the time of onset of the six GLP-1 RAs