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Important safety warnings include the risk of acute pancreatitis (patients should be advised to seek immediate medical attention if they experience persistent severe abdominal pain), gallbladder disease (including cholelithiasis and cholecystitis), dehydration-related acute kidney injury (particularly in patients with gastrointestinal side effects), and the need for careful monitoring of diabetic retinopathy in patients with pre-existing retinopathy, especially those on insulin