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The slices were transferred to a recording chamber and superfused constantly with carbogen (95% O 2 /5% CO 2 )-bubbled Ames medium (Sigma-Aldrich, Inc., St

In addition to its direct effects on beta cells, GIP also leads to increased glucagon secretion, and indirectly results in increased insulin secretion via communication between the alpha and beta cells of the pancreas (9)

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Ghrelin, a stomach-derived hormone that stimulates GH secretion, can be increased in individuals with PWS before the onset of obesity, which is a distinct feature not typically seen in common obesity or other genetic obesities (111, 112)

When combined with adequate protein intake and exercise, muscle loss can be minimized