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Salem V, Izzi-Engbeaya C, Coello C, Thomas DB, Chambers ES, Comninos AN, et al
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Complete non-response often points to receptor-level issues, either genetic polymorphisms that alter GLP-1 receptor binding, or downstream signaling problems that prevent the receptor activation from translating into metabolic changes
Nat Commun 11 , 1272 (2020)
How Akkermansia stimulates GLP-1 production Theres no denying that the gut microbiome and host metabolism are tightly intertwined
