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Loft, A

Br J Pharmacol 173:20952110

Lipotoxicity and Ectopic Fat Deposition When adipose tissues capacity to safely store excess nutrients is exceeded or functionally impaired, free fatty acids (FFAs) flux increases, resulting in ectopic lipid deposition in non-adipose organs such as the liver, pancreas, and skeletal muscle, thereby exacerbating insulin resistance and -cell stress [19]

New therapies have been designed with the aim of improving the results in efficacy and quality of life

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