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Notably, GLP-1 receptor activation in afferent arterioles induces vasodilation, thereby enhancing glomerular filtration while simultaneously reducing intraglomerular pressure

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Contrasting the latter, loss of liver Fgf21 expression did not attenuate liraglutide-induced weight loss in mice fed a high fat (60%), low carbohydrate diet, further suggesting that the contribution of Fgf21 to weight loss by liraglutide is dependent on dietary carbohydrate content

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Semaglutide (marketed under the brand name Wegovy) and liraglutide (Saxenda) did lead to weight loss, but it was significantly less at 15% and 8%, respectively