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doi: 10.1038/jcbfm.2015.17 84 LarssonMLietzauGNathansonDstensonCGMallardCJohanssonMEet al

Patients taking naltrexone regularly report that drinking feels less pleasurable

These medications are powerful tools, but they work best as part of a comprehensive approach to health that includes diet, exercise, and lifestyle changes

A randomized clinical trial comparing the effect of once-daily treatment of liraglutide and once-weekly treatment of semaglutide showed that adult patients treated with semaglutide for 68 weeks showed more than twice the decrease in body weight compared to people treated with liraglutide [80]
This can be seen as a problem due to lack of standardization or as a feature that actually makes the findings more robust: whatever design flaws exist in one study are probably absent from the rest
