dpp 4 inhibitors and glp 1 agonists together The Role of DPP-4 in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect Prescribing pearls: A guide to

They wrote a paper about all this like scientists do, and then nobody really did anything with it for the next 10 years

Acute Pancreatitis: Based on spontaneous postmarketing reports, acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing pancreatitis, has been observed in patients treated with liraglutide

doi: 10.1002/jnr.22565 74 PellecchiaMTPivonelloRLongoKManfrediMTessitoreAAmboniMet al

The therapeutic efficacy of GLP-1 is well established (3-5), and epigenetic modulation to amplify GLP-1 receptor (GLP-1R) action has been advocated as an option for the long-term glycemic control and reduction of obesity (6)

Future research should focus on understanding the long-term metabolic adaptations with these therapies, strategies for sustained weight loss, and long-term safety profile in various age groups