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Oral contraceptives, on the other hand, may cause headaches, mood changes, and changes in the menstrual cycle

The reason SURMOUNT-5 matters so much is that it is not just another placebo-controlled success story

The SURMOUNT-1 trial published in the New England Journal of Medicine (Jastreboff et al., 2022) showed average weight loss of 20.9 percent of body weight at the highest tirzepatide dose over 72 weeks

doi:10.1007/s40262-017-0532-6 56

Current clinical guidelines from major organizations including the American Diabetes Association (ADA) and the American Gastroenterological Association (AGA) do not specifically address combining tirzepatide with orlistat, reflecting the absence of robust clinical trial data for this combination