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The SURPASS-1 trial examined tirzepatide as monotherapy while the remaining SURPASS trials applied tirzepatide as an add-on to other glucose-lowering therapies comprised by metformin, insulin, SGLT2 inhibitors, sulfonylurea, or a combination of these

Topical interventions provide additional relief for select patients

In this study, half (50.0%) of the reported suicidal events occurred with semaglutide followed by liraglutide, whereas only four occurred with tirzepatide

Additionally, Jacobi et al

This "early worsening" phenomenon typically stabilizes with continued therapy but requires co-management with an ophthalmologist to determine appropriate individualized care