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, GLP-1 '' [=] = 'GLP-1 '

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By activating GLP-1 receptors in the brain, semaglutide sends signals that promote feelings of fullness and reduce the desire to overeat

[55] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake