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DISCLOSURES: All authors have served as consultants for Galderma
Dovizio et al, 2013

It is not known if Semaglutide will cause thyr oid tumors or a type of thyr oid cancer called medullary thyr oid carcinoma (MTC) in people Do not use Semaglutide if you or any of your family have ever had a type of thyr oid cancer called medullary thyr oid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Do not use Semaglutide if: you or any of your family have ever had a type of thyr oid cancer called medullary thyr oid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) you have had a serious allergic reaction to semaglutide or any of the ingredients in Semaglutide Before using Semaglutide, tell your healthcare provider if you have any other medical conditions, including if you: have or have had problems with your pancreas or kidneys have type 2 diabetes and a history of diabetic retinopathy have or have had depression, suicidal thoughts, or mental health issues are pregnant or plan to become pregnant

In GSE32269, gene expression values for GLP1R and the negative Notch signature genes ( ASCL1, DLL1,3,4, HEY1, HES6, DTX1 ) were isolated from the series matrix file, and a z-score was calculated from each genes TPM value [(x-)/] progression across patient samples (primary prostate cancer n=22, bone metastases n=29)

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