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Plateau and declining effectiveness affect some long-term users

All procedures were in accordance with the ethical standards of the institutional research committee and with the 1975 Declaration of Helsinki and its later amendments

Why people look for tirzepatide alternatives Before diving into the alternatives themselves, it helps to understand why someone would move away from tirzepatide in the first place

Data availability Data is provided within the manuscript

Acknowledgements The authors acknowledge Mayo Clinic librarians, Victoria Clifton and Tara Brigham, for their help with conducting the systematic review of the literature