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Ready for a clearer, structured approach

American Association of Clinical Endocrinologists Diabetes Mellitus Guidelines--2207

44 The combination of insulin and a GLP-receptor agonist A clinical trial published in The Lancet in 2014 compared the efficacy and safety of a fixed-ratio combination of insulin degludec and liraglutide (IDegLira) compared with its components given alone

A crowded field of next-generation contenders is also pushing forward: Amgen's AMG 133, Roche's GLP-1/GIP co-agonists, AstraZeneca's cotadutide, and Phase 2 candidates like HRS9531 and MariTide (a GLP-1 agonists plus GIP antagonist) are all showing early promise in obesity treatment

GLP-1 receptor agonists have a protective effect on the kidneys, reducing the risk of macroalbuminuria, but perhaps do not help preserve the glomerular filtration rate as much as sodium-glucose transporter-2 inhibitors