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On average, patients regain about 60% of the weight they lost within a few months to a year after stopping the medication, even when maintaining healthy habits like proper nutrition and exercise

22 In addition, certain pharmacological approaches to weight reduction, such as orlistat and topiramate, may promote kidney stone formation 23 : Orlistat, a lipase inhibitor, leads to fat accumulation in the intestine that binds to calcium, leading to enhanced intestinal oxalate absorption

GLP-1 medications address multiple parts of this equation simultaneously

Weight-Loss Surgery and Fitness The Dos and Donts for a Successful Exercise Program