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GI adverse events (mostly mild to moderate) were reported by 64% of participants in the 2.4 mg semaglutide group, 58% in the 1.0 mg semaglutide group and 34% in the placebo group

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Effects of sodium-glucose co-transporter 2 inhibitors on blood pressure: a systematic review and meta-analysis

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In the US, 2022 Q4 sales increased by a whopping 51 percent to $363.1 million, which the company said was primarily driven by increased demand and to a lesser extent, an increased Q4 2022 royalty from Boehringer Ingelheim for exceeding certain annual thresholds. The increased demand has likely been driven by the expanded approval in heart failure, which was a significant one as Jardiance was the first drug to win approvals for the two major types of heart failure (reduced and preserved ejection fraction) in 2021 and 2022