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Cardiovascular considerations Oral estrogen slightly increases the risk of venous thromboembolism (blood clots)

So if youre overweight or obese, losing weight and maintaining a healthy weight can support hormone balance, including oestrogen and progesterone

Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men

However, chronic stimulation of these paracrine myofibroblast pathways in IBD raises theoretical safety concerns regarding stricturing, fibrosis risk, and the necessity for rigorous dysplasia surveillance, which remain critical hurdles for long-term clinical development

doi: 10.2337/dci23-0100 18 DashS