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Ziffra et al., 2021)

However, the scale of the decline significantly exceeded expectations

Key variations include the size of the eligible population (eg, expanding covered indications and current legislation provisions), assumptions about treatment uptake and adherence, and how medication costs and savings are modeled

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Many individuals find the injection regimen cumbersome, contributing to a high discontinuation rate, with some data showing that only about 20% continuing treatment beyond a year
