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Weight loss can vary among patients
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Use of Semaglutide and Tirzepatide in Patients with T1D and Genetic Forms of Obesity It has been documented that between 9% and 27% of patients using tirzepatide or semaglutide have little or no response to these weight loss medications (patients considered non-responders to incretin therapies), with lack of response being defined as less than 5% weight loss observed over an average treatment period of 72 weeks [140]

A growing body of evidence from obesity and diabetes cohorts indicates that weight loss alone improves cortisol and HPA axis function, and GLP-1 medications may provide an additional neurobiological boost beyond caloric deficit
